Distinct Characteristics of Endometrial and Decidual Macrophages and Regulation of Their Permissivity to HIV-1 Infection by SAMHD1

• DOI: 10.1128/jvi.01730-14
• Publication Date: 2014-11-13T05:06:32Z
• Authors: Héloïse Quillay; Hicham El Costa; Romain Marlin; Marion Duriez; Claude Cannou; Fabrice Chrétien; Hervé Fernandez; Anne Lebreton; Julien Ighil; Olivier Schwartz; Françoise Barré-S...; Marie-Thérèse Nug...; Elisabeth Menu
• Keywords: Decidua; Proinflammatory cytokine; SAMHD1

In order to develop strategies prevent HIV-1 (human immunodeficiency virus type 1) transmission, it is crucial better characterize target cells in the female reproductive tract (FRT) mucosae and identify effective innate responses. Control of infection decidua (the uterine mucosa during pregnancy) can serve as a model study natural mucosal protection. Macrophages are main decidua. Here we report that vitro, macrophages T targets endometrium nonpregnant women. As reported for decidual (dM), endometrial (eM) were found have an M2-like phenotype (CD68+ CD163+ CD206+ IL-10high). However, eM dM may belong different subpopulations, they differently express certain markers secrete amounts proinflammatory anti-inflammatory cytokines. We observed strong expression SAMHD1 restriction factor weak its inactive form (pSAMHD1, phosphorylated at residue Thr592) both dM. Infection from tissues was enhanced presence viral protein Vpx, suggesting role infection. This further comparisons with FRT women should help mechanisms protection against infection.The major portals entry into body. The (uterine studying transmission. A comparison responses versus could protective mechanisms. Here, first time one restricted by SAMHD1. These findings might implications development vaccines