Vaccination To Induce Antibodies Blocking the CX3C-CX3CR1 Interaction of Respiratory Syncytial Virus G Protein Reduces Pulmonary Inflammation and Virus Replication in Mice

• DOI: 10.1128/jvi.01755-09
• Publication Date: 2009-10-29T00:45:26Z
• Authors: Wenliang Zhang; Youngjoo Choi; Lia M. Haynes; Jennifer L. Harcourt; Larry J. Anderson; Les P. Jones; Ralph A. Tripp
• Keywords: Replication

ABSTRACT Respiratory syncytial virus (RSV) infection causes substantial morbidity and some deaths in the young elderly worldwide. There is no safe effective vaccine available, although it possible to reduce hospitalization rate for high-risk children by anti-RSV antibody prophylaxis. RSV has been shown modify immune response infection, a feature linked part G protein CX3C chemokine mimicry. This study determined if vaccination with polypeptides or peptides spanning central conserved region of could induce antibodies that blocked CX3C-CX3CR1 interaction disease pathogenesis mediated infection. The results show mice vaccinated containing motif generate inhibit binding chemotaxis, lung titers, prevent body weight loss pulmonary inflammation. suggest vaccines block may offer new, safe, efficacious strategy.