The Mouse Cytomegalovirus G Protein-Coupled Receptor Homolog, M33, Coordinates Key Features of In Vivo Infection via Distinct Components of Its Signaling Repertoire

• DOI: 10.1128/jvi.01867-21
• Publication Date: 2021-12-08T18:38:55Z
• Authors: Jiawei Ma; Kimberley Bruce; Nicholas Davis-Po...; Philip G. Stevenson; Helen E. Farrell
• Keywords: Cytomegalovirus

G protein-coupled receptors (GPCRs) act as cell surface molecular “switches” that regulate the cellular response to environmental stimuli. All cytomegalovirus (CMV) genomes analyzed date possess GPCR homologs with phylogenetic evidence for independent gene capture events, signifying important in vivo roles.