Homologous Recombination in E3 Genes of Human Adenovirus Species D

• DOI: 10.1128/jvi.01927-13
• Publication Date: 2013-09-12T02:23:49Z
• Authors: Gurdeep Singh; Christopher M. Ro...; Shoaleh Dehghan; Morris S. Jones; David W. Dyer; Donald Seto; James Chodosh
• Keywords: Transcription; Adenovirus genome

Genes within the E3 transcription unit of human adenoviruses modulate host immune responses to infection. A comprehensive genomics and bioinformatics analysis for 38 viruses adenovirus species D (HAdV-D) revealed distinct surprising patterns homologous recombination. Homologous recombination was identified in open reading frames CR1α, CR1β, CR1γ, similar that previously observed with genes encoding three major structural capsid proteins, penton base, hexon, fiber.