A MicroRNA Encoded by Autographa californica Nucleopolyhedrovirus Regulates Expression of Viral Gene ODV-E25

• DOI: 10.1128/jvi.02112-13
• Publication Date: 2013-09-12T02:23:49Z
• Authors: Mengxiao Zhu; Jinwen Wang; Riqiang Deng; Peiwen Xiong; Hai Liang; Xunzhang Wang
• Keywords: Autographa californica; Coding region

ABSTRACT Baculovirus-encoded microRNAs (miRNAs) have been described in Bombyx mori nucleopolyhedrovirus; however, most of their functions remain unclear. Here we report the identification and characterization an miRNA encoded by Autographa californica nucleopolyhedrovirus. The identified miRNA, AcMNPV-miR-1, perfectly matched a segment coding sequence viral gene ODV-E25 downregulated mRNA expression, which likely resulted reduction infectious budded virions accelerated formation occlusion-derived virions.