N -Glycolylneuraminic Acid Binding of Avian and Equine H7 Influenza A Viruses

• DOI: 10.1128/jvi.02120-21
• Publication Date: 2022-01-19T16:26:14Z
• Authors: Cindy M. Spruit; Xueyong Zhu; Ilhan Tomris; María Ríos-Carrasco; Alvin X. Han; Frederik Broszeit; Roosmarijn van de...; Kim M. Bouwman; Michel M. T. Luu; Keita Matsuno; Yoshihiro Sakoda; Colin A. Russell; Ian A. Wilson; Geert-Jan Boons; Robert P. de Vries
• Keywords: N-glycolylneuraminic acid; Immunology; Influenza A Virus, H7N7 Subtype; Hemagglutinin Glycoproteins, Influenza Virus; Microbiology; Receptor-ligand interaction; 03 medical and health sciences; Polysaccharides; Virology; Animals; Humans; Glycan array; Horses; Hemagglutinin; Phylogeny; 0303 health sciences; Influenza; Sialic acid; N-Acetylneuraminic Acid; Virus-Cell Interactions; 3. Good health; Insect Science; NeuGc; Neuraminic Acids; H7; Protein Binding

Influenza A viruses cause millions of cases of severe illness and deaths annually. To initiate infection and replicate, the virus first needs to bind to a structure on the cell surface, like a key fitting in a lock.