IFP35 Is Involved in the Antiviral Function of Interferon by Association with the Viral Tas Transactivator of Bovine Foamy Virus

• DOI: 10.1128/jvi.02249-07
• Publication Date: 2008-02-28T01:58:47Z
• Authors: Juan Tan; Wentao Qiao; Jian Wang; Fengwen Xu; Yue Li; Jun Zhou; Qimin Chen; Yunqi Geng
• Keywords: Transcription; Viral protein; Viral structural protein; Viral life cycle

Interferon-induced proteins (IFPs) exert multiple functions corresponding to diverse interferon signals. However, the intracellular of many IFPs are not fully characterized. Here, we report that IFP35, a member IFP family with molecular mass 35 kDa, can interact bovine Tas (BTas) regulatory protein foamy virus (BFV). The interaction involves NID2 (IFP35/Nmi homology domain) IFP35 and central domain BTas. overexpression disturbs ability BTas activate viral-gene transcription inhibits viral replication. depletion endogenous by interfering RNA promote activation BFV, suggesting an inhibitory function in expression. In addition, homologous prototype FV arrest replication repress transcription. Our study suggests may represent novel pathway interferon-mediated antiviral activity host organisms plays role maintenance latency.