Inhibition of 2′,5′-Oligoadenylate Synthetase Expression and Function by the Human Cytomegalovirus ORF94 Gene Product

• DOI: 10.1128/jvi.02463-10
• Publication Date: 2011-03-31T01:59:24Z
• Authors: Joanne C. G. Tan; Selmir Avdic; John Z. Cao; Edward S. Mocarski; Kirsten L. White; Allison Abendroth; Barry Slobedman
• Keywords: Cytomegalovirus; Interferon-stimulated gene

The human cytomegalovirus (HCMV) ORF94 gene product has been reported to be expressed during both productive and latent phases of infection, although its function is unknown. We report that expression pORF94 leads decreased 2',5'-oligoadenylate synthetase (OAS) in transfected cells with without interferon stimulation. Furthermore, the functional activity OAS was inhibited by pORF94. Finally, we present evidence modulation HCMV infection fibroblasts. This study provides first identification a for identifies an additional means which may limit critical host cell antiviral response.