Susceptibility of Human Iris Stromal Cells to Herpes Simplex Virus 1 Entry

• DOI: 10.1128/jvi.03235-12
• Publication Date: 2013-01-24T01:35:12Z
• Authors: John Baldwin; Paul J. Park; Brian Zanotti; Erika Maus; Michael V. Volin; Deepak Shukla; Vaibhav Tiwari
• Keywords: IRIS (biosensor); HSL and HSV

ABSTRACT Ocular herpes simplex virus 1 (HSV-1) infection can lead to multiple complications, including iritis, an inflammation of the iris. Here, we use human iris stroma cells as a novel in vitro model demonstrate HSV-1 entry and inflammatory mediators that damage The upregulated cytokines observed this study provide new understanding intrinsic immune mechanisms contribute onset iritis.