Canine Distemper Virus Associated with a Lethal Outbreak in Monkeys Can Readily Adapt To Use Human Receptors

• DOI: 10.1128/jvi.03479-12
• Publication Date: 2013-04-18T00:17:19Z
• Authors: Kouji Sakai; Tomoki Yoshikawa; Fumio Seki; Shuetsu Fukushi; Maino Tahara; Noriyo Nagata; Yasushi Ami; Tetsuya Mizutani; Ichiro Kurane; Ryoji Yamaguchi; Hideki Hasegawa; Masayuki Saijo; Katsuhiro Komase; Shigeru Morikawa; Makoto Takeda
• Keywords: Canine distemper; Mononegavirales

ABSTRACT A canine distemper virus (CDV) strain, CYN07-dV, associated with a lethal outbreak in monkeys, used human signaling lymphocyte activation molecule as receptor only poorly but readily adapted to use it following P541S substitution the hemagglutinin protein. Since CYN07-dV had an intrinsic ability nectin-4, became able both immune and epithelial cell receptors, well monkey ones, suggesting that CDV can potentially infect humans.