Capacity for Infectious HIV-1 Virion Capture Differs by Envelope Antibody Specificity

• DOI: 10.1128/jvi.03765-13
• Publication Date: 2014-02-20T05:29:07Z
• Authors: Pinghuang Liu; LaTonya D. Williams; Xiaoying Shen; Mattia Bonsignori; Nathan A. Vanderg...; R. Glenn Overman; M. Anthony Moody; Hua-Xin Liao; Daniel J. Stieh; Kerrie L. McCotter; Audrey L. French; Thomas J. Hope; Robin Shattock; Barton F. Haynes; Georgia D. Tomaras
• Keywords: env Gene Products, Human Immunodeficiency Virus; Antibodies, Monoclonal; HIV Antibodies; Antibodies, Neutralizing; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Antibody Specificity; Immunoglobulin G; HIV-1; Animals; Female

Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the virion capture index (IVCI) different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured virions, non-bNAbs and mucosal human immunodeficiency type 1 (HIV-1)-positive IgG subsets both noninfectious virions. Infectious was additive with mixture antibodies, providing proof concept vaccine-induced that together have improved