Five Genome Sequences of Subspecies B1 Human Adenoviruses Associated with Acute Respiratory Disease

Adenovirus Infections, Human 0301 basic medicine 0303 health sciences 03 medical and health sciences Base Sequence Adenoviruses, Human Acute Disease Molecular Sequence Data Humans Genome, Viral Respiratory Tract Infections 3. Good health
DOI: 10.1128/jvi.06593-11 Publication Date: 2011-12-09T21:33:54Z
ABSTRACT
ABSTRACT Five genomes of human subspecies B1 adenoviruses isolated from cases of acute respiratory disease have been sequenced and archived for reference. These include representatives of two prevalent genomic variants of HAdV-7, i.e., HAdV-7h and HAdV-7d2. The other three are HAdV-3/16, HAdV-16 strain E26, and HAdV-3+7 strain Takeuchi. All are recombinant genomes. Genomics and bioinformatics provide detailed views into the genetic makeup of these pathogens and insight into their molecular evolution. Retrospective characterization of particularly problematic older pathogens such as HAdV-7h (1987) and intriguing isolates such as HAdV-3+7 strain Takeuchi (1958) may provide clues to their phenotypes and serology and may suggest protocols for prevention and treatment.
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