Five Genome Sequences of Subspecies B1 Human Adenoviruses Associated with Acute Respiratory Disease

• DOI: 10.1128/jvi.06593-11
• Publication Date: 2011-12-09T21:33:54Z
• Authors: Shoaleh Dehghan; Elizabeth B. Liu; Jason Seto; Sarah F. Torres; Nolan R. Hudson; Adriana E. Kajon; David Metzgar; David W. Dyer; James Chodosh; Morris S. Jones; Donald Seto
• Keywords: Adenovirus Infections, Human; 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Base Sequence; Adenoviruses, Human; Acute Disease; Molecular Sequence Data; Humans; Genome, Viral; Respiratory Tract Infections; 3. Good health

ABSTRACT Five genomes of human subspecies B1 adenoviruses isolated from cases of acute respiratory disease have been sequenced and archived for reference. These include representatives of two prevalent genomic variants of HAdV-7, i.e., HAdV-7h and HAdV-7d2. The other three are HAdV-3/16, HAdV-16 strain E26, and HAdV-3+7 strain Takeuchi. All are recombinant genomes. Genomics and bioinformatics provide detailed views into the genetic makeup of these pathogens and insight into their molecular evolution. Retrospective characterization of particularly problematic older pathogens such as HAdV-7h (1987) and intriguing isolates such as HAdV-3+7 strain Takeuchi (1958) may provide clues to their phenotypes and serology and may suggest protocols for prevention and treatment.