Induction of B-Cell Lymphoma in BALB/c Nude Mice with an Ecotropic, B-Tropic Helper Virus Present in the Murine AIDS Virus Stock

• DOI: 10.1128/jvi.73.2.1640-1644.1999
• Publication Date: 2019-12-31T18:23:49Z
• Authors: Lamin Tayar; Kyoko Higo; Yoshinao Kubo; Yun Wang; Ling-Min Lu; Fengmin Zhang; Yasumasa Iwatani; Ling Wang; Takeshi Ono; Michiyuki Maeda; Hiroyuki Sakai; Akinori Ishimoto
• Keywords: B-Lymphocytes; Mice, Inbred BALB C; 0303 health sciences; Lymphoma, B-Cell; Mice, Nude; 3. Good health; Leukemia Virus, Murine; Mice; 03 medical and health sciences; Murine Acquired Immunodeficiency Syndrome; DNA, Viral; Animals; Helper Viruses

ABSTRACTThe pathogenicities of the murine AIDS (MAIDS) virus complex (LP-BM5) and ecotropic helper virus (BM5eco) isolated from the complex to BALB/c nude mice were studied to elucidate the possible role of replication-competent helper virus in inducing the monoclonal outgrowth of lymphoid cells. Neither LP-BM5 nor BM5eco was pathogenic in adult BALB/c nude mice. However, B-cell lymphoma developed with a very high frequency when either virus was inoculated into newborn BALB/c nude (nu/nu) mice. The cells from the B-cell lymphoma were easily transplanted into nude mice. These results suggested that ecotropic helper virus in the MAIDS virus complex plays an important role in inducing the monoclonal outgrowth of lymphoid cells under immunodeficient conditions caused by defective virus.