Latent Antigen Vaccination in a Model Gammaherpesvirus Infection

• DOI: 10.1128/jvi.75.17.8283-8288.2001
• Publication Date: 2002-07-27T10:06:37Z
• Authors: Edward J. Usherwood; Kimberley A. Ward; Marcia A. Blackman; James P. Stewart; David L. Woodland
• Keywords: Virus latency; Latent Virus

ABSTRACT Vaccines that can reduce the load of latent gammaherpesvirus infections are eagerly sought. One attractive strategy is vaccination against latency-associated proteins, which may increase efficiency with T cells recognize and eliminate latently infected cells. However, due to lack tractable animal model systems, effect latent-antigen on latency not known. Here we use murine investigate impact M2 antigen. As expected, had no acute lung infection. there was a significant reduction in initial stages infection, when expressed. These data show for first time level vivo suggest strategies involving other antigens ultimately be successfully used long-term