Intersubtype Human Immunodeficiency Virus Type 1 Superinfection following Seroconversion to Primary Infection in Two Injection Drug Users

• DOI: 10.1128/jvi.76.15.7444-7452.2002
• Publication Date: 2002-07-28T23:07:23Z
• Authors: Artur Ramos; Dale J. Hu; Lily Nguyen; Kim-Oanh Phan; Suphak Vanichseni; Nattawan Promadej; Kachit Choopanya; Margaret Callahan; Nancy L. Young; Janet McNicholl; Timothy D. Mastro; Thomas M. Folks; Shambavi Subbarao
• Keywords: Superinfection; Seroconversion

ABSTRACT In this study, we describe two cases of human immunodeficiency virus type 1 (HIV-1) intersubtype superinfection with CRF01_AE and subtype B strains, which occurred in injection drug users participating a prospective cohort study Bangkok, Thailand. both cases, the superinfecting strain was detected by molecular serologic analyses several weeks after complete seroconversion to primary infection belonging different subtype. Superinfection despite specific T-cell humoral antibody responses virus. cross-subtype immune were limited or absent prior second infection. These data show that, some individuals, quality quantity response elicited HIV-1 may not protect against superinfection. This finding has important implications for vaccine design. vaccines, at minimum, will need include potent, broadly protective, conserved immunogens derived from group M subtypes.