CD8+T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection

• DOI: 10.1128/jvi.77.1.68-76.2003
• Publication Date: 2002-12-11T19:22:58Z
• Authors: Robert Thimme; Stefan Wieland; Carola Steiger; John Ghrayeb; Keith A. Reimann; Robert H. Purcell; Francis V. Chisari
• Keywords: Pathogenesis; Viral Pathogenesis

Although the CD4(+)- and CD8(+)-T-cell responses to hepatitis B virus (HBV) are thought be crucial for control of HBV infection, relative contribution each T-cell subset as an effector viral clearance is not known. To examine this question, we monitored course infection in control, CD4-depleted, CD8-depleted chimpanzees. Our results demonstrate that CD8(+) cells main responsible disease pathogenesis during acute they suggest mediated by both noncytolytic cytolytic functions response.