Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication

• DOI: 10.1128/jvi.78.11.6073-6076.2004
• Publication Date: 2004-05-12T20:28:03Z
• Authors: Yong-Hui Zheng; Dan Irwin; Takeshi Kurosu; Kenzo Tokunaga; Tetsutaro Sata; B. Matija Peterlin
• Keywords: APOBEC3G; APOBEC; Host factors; Retrotransposon

Recently, APOBEC3G has been identified as a host factor that blocks retroviral replication. It introduces G to A hypermutations in newly synthesized minus strand viral cDNA at the step of reverse transcription target cells. Here, we human APOBEC3F protein another immunodeficiency virus type 1 (HIV-1) Similar APOBEC3G, also induced HIV genomic DNA, and Vif counteracted its activity. Thus, APOBEC family members might have evolved general defense mechanism body against retroviruses, retrotransposons, other mobile genetic elements.