The Amino-Terminal Region of Major Capsid Protein P3 Is Essential for Self-Assembly of Single-Shelled Core-Like Particles of Rice Dwarf Virus
Models, Molecular
0301 basic medicine
0303 health sciences
Virus Assembly
Virion
Oryza
Reoviridae
Nucleopolyhedroviruses
Cell Line
3. Good health
Structure-Activity Relationship
03 medical and health sciences
Animals
Capsid Proteins
Dimerization
Gene Deletion
DOI:
10.1128/jvi.78.6.3145-3148.2004
Publication Date:
2004-02-27T21:47:38Z
AUTHORS (9)
ABSTRACT
The core protein P3 of Rice dwarf virus constructs asymmetric dimers, one which is inserted by the amino-terminal region another protein. proteins with serial deletions, expressed in a baculovirus system, formed particles gradually decreasing stability. capacity for self-assembly disappeared when 52 amino acids had been deleted. These results demonstrated that insertion arm into appears to play an important role stabilizing particles.
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