Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex

• DOI: 10.1128/mbio.00510-23
• Publication Date: 2023-04-13T14:48:53Z
• Authors: Beth Mann; Jeremy Chase Craw...; Kavya Reddy; Josi Lott; Yong Ha Youn; Geli Gao; Cliff Guy; Ching-Heng Chou; Daniel Darnell; Sanchit Trivedi; Perrine Bomme; Allister J. Loughran; Paul G. Thomas; Young-Goo Han; Elaine I. Tuomanen
• Keywords: Neocortex; Ligands; hedgehog signaling; Microbiology; QR1-502; Toll-Like Receptor 2; 3. Good health; Toll-like receptors; Toll-Like Receptor 6; Pregnancy; neocortex; cell wall; Humans; Female; Hedgehog Proteins; Research Article

Fetal brain development in early gestation can be impacted by transplacental infection, altered metabolites from the maternal microbiome, or maternal immune activation. It is less well understood how maternal microbial subcomponents that cross the placenta, such as bacterial cell wall (BCW), directly interact with fetal neural progenitors and neurons and affect development.