Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

• DOI: 10.1128/mbio.00632-19
• Publication Date: 2019-05-06T18:09:19Z
• Authors: John P. Haran; Shakti K. Bhattarai; Sage E. Foley; Protiva Dutta; Doyle V. Ward; Vanni Bucci; Beth A. McCormick
• Keywords: Male; ATP Binding Cassette Transporter, Subfamily B; 610; Nervous System; elderly; Microbiology; Machine Learning; Feces; 03 medical and health sciences; Alzheimer Disease; Homeostasis; Humans; Alzheimer’s Disease; Prospective Studies; Immunology and Infectious Disease; Aged; Aged, 80 and over; Inflammation; 0303 health sciences; Environmental Microbiology and Microbial Ecology; Neuroscience and Neurobiology; Bacteria; gut-brain axis; Mental Disorders; intestinal homeostasis; Epithelial Cells; intestinal microbiome; QR1-502; Gastrointestinal Microbiome; 3. Good health; Cellular and Molecular Physiology; Intestines; Medical Microbiology; Dysbiosis; Dementia; Female; Metagenomics; Nervous System Diseases; Digestive System; Metabolic Networks and Pathways; dementia; Research Article

Studies of the intestinal microbiome and AD have demonstrated associations with composition at genus level among matched cohorts. We move this body literature forward by more deeply investigating via metagenomics comparing patients against those without dementia other types. also exploit machine learning approaches that combine both metagenomic clinical data. Finally, our functional studies using stool samples from elders demonstrate how c can affect health dysregulation P-glycoprotein pathway. contributes directly to inflammatory disorders intestine. Since has been long thought be linked chronic bacterial infections as a possible etiology, findings therefore fill gap in knowledge field research identifying nexus between microbiome, loss homeostasis, inflammation may underlie neurodegenerative disorder.