Combination Adjuvants Enhance Recombinant Protein Vaccine Protection against Fungal Infection

• DOI: 10.1128/mbio.02018-21
• Publication Date: 2021-08-17T08:32:02Z
• Authors: Marcel Wüthrich; Hannah E. Dobson; Cleison Ledesma T...; Uju Joy Okaa; Lucas dos Santos ...; Marcos Isidoro-Ayza; Nikolai Petrovsky; Bruce S. Klein
• Keywords: CD4-Positive T-Lymphocytes; Male; T cells; CD8-Positive T-Lymphocytes; immunization; Microbiology; Blastomycosis; Interferon-gamma; Mice; 03 medical and health sciences; Adjuvants, Immunologic; Animals; Immunity, Cellular; Vaccines, Synthetic; 0303 health sciences; Inulin; QR1-502; 3. Good health; Mice, Inbred C57BL; Mycoses; adjuvants; Blastomyces; Female; fungi; Fungal Vaccines; Research Article

Fungal disease remains a challenging clinical and public health problem. Despite medical advances, invasive fungal infections have skyrocketed over the last decade and pose a mounting health threat in immunocompetent and -deficient hosts, with worldwide mortality rates ranking 7th, even ahead of tuberculosis.