The Epstein-Barr Virus Oncogene EBNA1 Suppresses Natural Killer Cell Responses and Apoptosis Early after Infection of Peripheral B Cells

• DOI: 10.1128/mbio.02243-21
• Publication Date: 2021-11-16T09:31:08Z
• Authors: Danielle Westhoff...; Adityarup Chakrav...; Mitch Hayes; Wolfgang Hammersc...; Bill Sugden
• Keywords: 0301 basic medicine; B cell; herpesviruses; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Intracellular Signaling Peptides and Proteins; Apoptosis; GPI-Linked Proteins; Microbiology; QR1-502; Cell Line; 3. Good health; Killer Cells, Natural; 03 medical and health sciences; c-Myc; Epstein-Barr Virus Nuclear Antigens; Memory B Cells; Host-Pathogen Interactions; ULBP; Epstein-Barr virus; Humans; innate immunity; Research Article

Epstein-Barr virus (EBV) is a ubiquitous human pathogen, infecting up to 95% of the world’s adult population. Initial infection with EBV can cause infectious mononucleosis.