Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum

• DOI: 10.1128/mbio.02710-21
• Publication Date: 2021-11-09T09:30:29Z
• Authors: Heather M. Evans; Destiny F. Schultz; Adam J. Boiman; Melanie C. McKell; Joseph E. Qualls; George S. Deepe
• Keywords: 0301 basic medicine; mitochondrial metabolism; Macrophages; Citric Acid Cycle; Histoplasma; Hypoxia-Inducible Factor 1, alpha Subunit; Microbiology; QR1-502; lung; Interleukin-10; 3. Good health; Mice; MicroRNAs; 03 medical and health sciences; Fumarates; hypoxia inducible factor 1; Animals; Humans; innate immunity; Histoplasmosis; Research Article

Histoplasma capsulatumand relatedHistoplasmaspecies are intracellular fungal pathogens endemic to broad regions of the globe, including the Americas, Africa, and Asia. While most infections resolve with mild or no symptoms, failure of the host to control fungal growth produces severe disease.