Inhibition of Neutrophil Primary Granule Release during Yersinia pestis Pulmonary Infection

• DOI: 10.1128/mbio.02759-19
• Publication Date: 2019-12-09T11:07:23Z
• Authors: Kara R. Eichelberger; Grant S. Jones; William E. Goldman
• Keywords: Yersinia pestis; plague; Yersiniosis

Yersinia pestis is the causative agent of plague and one deadliest human pathogens. The pneumonic form Y. infection has played a critical role in severity both historical modern outbreaks, yet host-pathogen interactions that govern lethality pulmonary infections are incompletely understood. Here, we report inhibits neutrophil degranulation during infection, rendering neutrophils ineffective allowing unrestricted growth lungs. This coordinated inhibition granule release not only demonstrates pathogenic benefit “silencing” lung but also reveals specific host processes pathways could be manipulated to reduce primary plague.