Gut Feelings Begin in Childhood: the Gut Metagenome Correlates with Early Environment, Caregiving, and Behavior

• DOI: 10.1128/mbio.02780-19
• Publication Date: 2020-01-20T09:38:05Z
• Authors: Jessica E. Flannery; Keaton Stagaman; Adam R. Burns; Roxana J. Hickey; Leslie E. Roos; Ryan J. Giuliano; Philip A. Fisher; Thomas J. Sharpton
• Keywords: Male; 0301 basic medicine; 2. Zero hunger; metagenomics; behavior; microbiome; Child Behavior; Environment; Models, Theoretical; Microbiology; QR1-502; Gastrointestinal Microbiome; 03 medical and health sciences; Caregivers; Socioeconomic Factors; Animals; Humans; Metagenome; Female; Metagenomics; Child; development; childhood; Research Article

Childhood is a formative period of behavioral and biological development that can be modified, for better or worse, by the psychosocial environment that is in part determined by caregivers. Not only do our own genes and the external environment influence such developmental trajectories, but the community of microbes living in, on, and around our bodies—the microbiome—plays an important role as well. By surveying the gut microbiomes of a cross-sectional cohort of early school-aged children with a range of psychosocial environments and subclinical mental health symptoms, we demonstrated that caregiving behaviors modified the child gut microbiome’s association to socioeconomic risk and behavioral dysregulation.