SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators

• DOI: 10.1128/mbio.03136-22
• Publication Date: 2023-01-10T14:06:10Z
• Authors: Jose M. Honrubia; Javier Gutierrez-...; Alejandro Sanz-Bravo; Ezequiel González...; Diego Muñoz-Santos; Carlos Castaño-Ro...; Li Wang; Marta Villarejo-T...; Jorge Ripoll-Gómez; Ana Esteban; Raul Fernandez-De...; Pedro José Sánche...; Juan Carlos Oliveros; Stanley Perlman; Paul B. McCray; Isabel Sola; Luis Enjuanes
• Keywords: 0301 basic medicine; Virulence Factors; coronavirus; Cystic Fibrosis Transmembrane Conductance Regulator; envelope (E) protein; Microbiology; Mice; 03 medical and health sciences; antivirals; Animals; Humans; Lung edema resolution; RNA, Messenger; CFTR; lung edema resolution; Lung; SARS-CoV-2; COVID-19; Antivirals; QR1-502; Envelope (E) protein; 3. Good health; Coronavirus; Severe acute respiratory syndrome-related coronavirus; Middle East Respiratory Syndrome Coronavirus; Research Article

Three highly pathogenic human CoVs have been identified: SARS-CoV, MERS-CoV, and SARS-CoV-2. The E protein PBMs of these three CoVs were virulence factors.