Ammonia stress-induced heat shock factor 1 enhances white spot syndrome virus infection by targeting the interferon-like system in shrimp

• DOI: 10.1128/mbio.03136-23
• Publication Date: 2024-02-15T13:46:53Z
• Authors: Xin-Xin Wang; Hui Zhang; Jie Gao; Xian-Wei Wang
• Keywords: White spot syndrome; White (mutation)

Disease emergence is the consequence of host-pathogen-environment interactions. Ammonia a key stress factor in aquatic environments that usually increases risk pathogenic diseases animals. However, molecular regulatory mechanisms underlying enhancement viral infection following ammonia remain largely unknown. Here, we found enhances white spot syndrome virus kuruma shrimp (Marsupenaeus japonicus) by targeting antiviral interferon-like system through heat shock 1 (Hsf1). Hsf1 an ammonia-induced transcription factor. It regulates expression Cactus and Socs2, which encode negative regulators NF-κB signaling Jak/Stat signaling, respectively. By inhibiting these two pathways, suppressed production function MjVago-L, arthropod interferon analog. Therefore, this study revealed central regulator immunity after provides new insights into regulation stressful environments. end product protein catabolism derived from feces unconsumed foods. threatens health growth In study, demonstrated suppresses (Hsf1) process. When are stressed ammonia, they activate for relief well-being. upregulates inhibit analogs shrimp, thereby enhancing infection. perspective, explains problem aquaculture industry animals living more susceptible to pathogens than those unstressed conditions. Moreover, side effects responses highlights complexity achieving cellular homeostasis under