Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

• DOI: 10.1128/mbio.03400-21
• Publication Date: 2022-01-04T13:07:55Z
• Authors: Elaine M. Kohn; Cleison Taira; Hanah Dobson; Lucas Dos Santos ...; Uju Okaa; Darin L. Wiesner; Marcel Wüthrich; Bruce S. Klein
• Keywords: 0303 health sciences; mice; Mice, Inbred Strains; adaptive immunity; immunity; Microbiology; blastomycosis; QR1-502; Immunophenotyping; resistance; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Mice, Inbred DBA; Mice, Inbred NOD; Blastomyces; Animals; fungi; Research Article

Host genetic variation significantly impacts vulnerability to infectious diseases. While host variation in susceptibility to fungal infection with dimorphic fungi has long been recognized, genes that underpin this variation are poorly understood.