Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites

• DOI: 10.1128/mbio.03478-21
• Publication Date: 2022-01-25T09:30:51Z
• Authors: Gabriela de A. Bu...; Nailma S. A. dos ...; Júlia T. de Castro; Fernanda L. B. Mugge; Viviane Grazielle...; Antônio Edson R. ...; Milton C. A. Pereira; João Luís Reis-Cunha; Anderson Coqueiro...; Dawidson Assis Gomes; Daniella C. Barth...; Nilmar S. Moretti; Sergio Schenkman; Ricardo T. Gazzin...; Santuza M. R. Tei...
• Keywords: Chagas Disease

Trypanosoma cruzi is the causative agent of Chagas disease, a neglected tropical disease that affects approximately 6 to 8 million people and for which there no effective treatment or vaccine. The parasite expresses family surface proteins, named trans-sialidases, responsible transferring sialic acid from host glycoconjugates mucins.