Molecular Basis of Rhodomyrtone Resistance in Staphylococcus aureus

• DOI: 10.1128/mbio.03833-21
• Publication Date: 2022-02-15T09:31:00Z
• Authors: Li Huang; Miki Matsuo; Carlos Calderón; Sook-Ha Fan; Aparna Viswanatha...; Xiaoqing Fu; Ningna Li; Arif Luqman; Marvin Ullrich; Florian Herrmann; Martin Maier; Anchun Cheng; Fajun Zhang; Filipp Oesterhelt; Michael Lämmerhofer; Friedrich Götz
• Keywords: Staphylococcus aureus; 0303 health sciences; FarE; P-lipids; Xanthones; Microbial Sensitivity Tests; Microbiology; QR1-502; isothermal titration calorimetry; Anti-Bacterial Agents; 3. Good health; 03 medical and health sciences; Anti-Infective Agents; Bacterial Proteins; lipidomic analysis; rhodomyrtone; Drug Resistance, Bacterial; FarR; Research Article

Antibiotic resistance is a growing public health problem, and alternative antibiotics are urgently needed. Rhodomyrtone (Rom), an antimicrobial compound originally isolated from Rhodomyrtus tomentosa , is active against multiple resistant Gram-positive pathogens.