The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G0 Cell State From a G1 Cell State

• DOI: 10.1128/mcb.16.12.6965
• Publication Date: 2015-10-09T00:26:57Z
• Authors: Eric J. Smith; Gustavo Leone; James DeGregori; Laszlo Jakoi; Joseph R. Nevins
• Keywords: E2F; Retinoblastoma protein

Previous studies have demonstrated cell cycle-dependent specificities in the interactions of E2F proteins with Rb family members. We now show that formation an E2F-p130 complex is unique to cells a quiescent, G0 state. The does not reform when reenter proliferative state and cycle through G1. presence quiescent coincides E2F-mediated repression transcription E2F1 gene, we sites promoter are important as enter quiescence but play no apparent role cycling cells. In addition, decay requires action G1 cyclin-dependent kinase activity. conclude accumulation provides negative control certain key target genes defines functional distinction between these exist transiently