Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control

• DOI: 10.1128/mcb.22.4.1094-1105.2002
• Publication Date: 2002-07-27T09:55:53Z
• Authors: Jene Choi; Bonnie Nannenga; Oleg N. Demidov; Dmitry V. Bulavin; Austin Cooney; Cory Brayton; Yongxin Zhang; Innocent N. Mbawuike; Allan Bradley; Ettore Appella; Lawrence A. Doneh...
• Keywords: Cyclin-Dependent Kinase Inhibitor p21; Male; B-Lymphocytes; Mice, Inbred BALB C; 0303 health sciences; Cell Cycle; Mice, Transgenic; Kidney; Neoplasm Proteins; Mice, Inbred C57BL; Embryonic and Fetal Development; Mice; 03 medical and health sciences; Gene Expression Regulation; Cyclins; Immune System; Gene Targeting; Animals; Body Constitution; Humans; Female; In Situ Hybridization

The Wip1 gene is a serine/threonine phosphatase that induced in p53-dependent manner by DNAdamaging agents.We show here message expressed moderate levels all organs, but present at very high the testes, particularly postmeiotic round spermatid compartment of seminiferous tubules.We have confirmed mRNA ionizing radiation mouse tissues manner.To further determine normal biological function mammalian organisms, we generated Wip1-deficient mice.Wip1 null mice are viable variety postnatal abnormalities, including variable male runting, reproductive organ atrophy, reduced fertility, and longevity.Mice lacking increased susceptibility to pathogens diminished T-and B-cell function.Fibroblasts derived from embryos decreased proliferation rates appear be compromised entering mitosis.The data consistent with an important role for spermatogenesis, lymphoid cell function, cycle regulation.