Expression of a Proto-Oncogene (Proto-myb) in Hemopoietic Tissues of Mice

• DOI: 10.1128/mcb.4.7.1206-1212.1984
• Publication Date: 2021-06-07T02:09:39Z
• Authors: Diana Sheiness; Minnetta Gardinier
• Keywords: MYB; Northern blot; Involution (esoterism)

This study addressed the possibility that proto-myb (also called c-myb), cellular homolog of a retroviral transforming gene, plays role in hemopoiesis, particularly during maturation T cells. By gel blot hybridization, we confirmed previous reports transcripts are found at much higher levels thymic lymphocytes and cells erythroid lineage than other tissue sources. Using dot hybridizations, demonstrated further similar expression taken from young mice with active thymuses old whose have undergone involution extent decreases least 10-fold as progress immature cortical thymocytes to mature, resting lymph nodes. These results suggest protein product functions T-cell differentiation.