Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes.

• DOI: 10.1128/mcb.5.10.2720
• Publication Date: 2015-09-30T19:34:21Z
• Authors: S Y Ng; P Gunning; R Eddy; P Ponte; J Leavitt; T Shows; L Kedes
• Keywords: Pseudogene; Conserved sequence; Coding region

We have assigned six members of the human beta-actin multigene family to specific chromosomes. The functional gene, ACTB, is located on chromosome 7, and other beta-actin-related sequences are dispersed over at least four different chromosomes including one locus X chromosome. Using intervening sequence probes, we showed that gene single copy all related recently generated in evolution probably processed pseudogenes. entire nucleotide has been determined identical cDNA clones coding 5' untranslated regions. previously reported 3' region well conserved between humans rats (Ponte et al., Nucleic Acids Res. 12:1687-1696, 1984). Now report additional noncoding regions evolutionarily conserved, segments flanking region, and, surprisingly, I III. These sequences, especially those found introns, suggest a role for internal regulation expression.