Estrogen Attenuates the Growth of Human Papillomavirus-Positive Epithelial Cells

• DOI: 10.1128/msphere.00049-20
• Publication Date: 2020-03-17T12:45:27Z
• Authors: Molly L. Bristol; Claire D. James; Xu Wang; Christian T. Fontan; Iain M. Morgan
• Keywords: 0301 basic medicine; HPV; Papillomavirus E7 Proteins; keratinocyte; HNSCC; Microbiology; 03 medical and health sciences; Cell Line, Tumor; estrogen; cancer; Humans; Cell Proliferation; Human papillomavirus 16; Squamous Cell Carcinoma of Head and Neck; Papillomavirus Infections; Estrogen Receptor alpha; Epithelial Cells; Estrogens; Oncogene Proteins, Viral; QR1-502; 3. Good health; Repressor Proteins; Head and Neck Neoplasms; transcription; Research Article

Human papillomaviruses cause around 5% of all human cancers, yet there are no specific antiviral therapeutic approaches available for combatting these cancers. These cancers currently treated with standard chemoradiation therapy (CRT). Specific reagents desperately required, particularly HPV+HNSCC whose incidence is increasing and which diagnostic tools this disease. Using data from The Cancer Genome Atlas (TCGA), we others determined that the estrogen receptor alpha (ERα) overexpressed in elevated levels associated an improved disease outcome. This has led to proposal treatment could be a novel approach HPV+cancers. Here, demonstrate attenuates growth HPV+epithelial cells using multiple mechanisms, supporting idea potential as agent HPV+HNSCC.