CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge

• DOI: 10.1128/msphere.00058-21
• Publication Date: 2021-06-03T15:44:11Z
• Authors: Yan Yan; Kai Hu; Ming Fu; Xu Deng; Sukun Luo; Lina Tong; Xinmeng Guan; Siyi He; Chang Li; Wei Jin; Tao Du; Zifeng Zheng; Mudan Zhang; Yalan Liu; Qinxue Hu
• Keywords: CCL19; Immunogen

An effective HSV-2 vaccine should induce antigen (Ag)-specific immune responses against viral mucosal infection. This study reveals that chemokine CCL19 or CCL28 enhanced glycoprotein D ectodomain (gD-306aa)-induced vaginal virus challenge.