Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

• DOI: 10.1128/msphere.00520-19
• Publication Date: 2019-09-24T11:08:11Z
• Authors: Fikri Avci; Francesco Berti; Peter Dull; John Hennessey; Viliam Pavliak; A. Krishna Prasad; Willie Vann; Michael Wacker; Olivier Marcq
• Keywords: Glycoconjugate

Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in clinic. The lack fundamental understanding factors controlling clinical efficacy glycoconjugate is discussed while key parameters demanding focused and collaborative research identified.