The Lipid Raft-Associated Protein Stomatin Is Required for Accumulation of Dectin-1 in the Phagosomal Membrane and for Full Activity of Macrophages against Aspergillus fumigatus

• DOI: 10.1128/msphere.00523-22
• Publication Date: 2023-01-31T14:11:39Z
• Authors: Marie Goldmann; Franziska Schmidt; Zoltán Cseresnyés; Thomas Orasch; Susanne Jahreis; Susann Hartung; Marc Thilo Figge; Marie von Lilienf...; Thorsten Heinekamp; Axel A. Brakhage
• Keywords: Lipid raft

Stomatin is an integral membrane protein that contributes to the uptake of microbes, e.g., spores human-pathogenic fungus Aspergillus fumigatus . By generation a stomatin-deficient macrophage line by advanced genetic engineering, we found stomatin involved in recruitment β-glucan receptor dectin-1 phagosomal macrophages.