Tetrasodium EDTA Is Effective at Eradicating Biofilms Formed by Clinically Relevant Microorganisms from Patients’ Central Venous Catheters

0301 basic medicine Canada antibiotic resistance Bacteria EDTA Fungi Microbiology Gram-negative QR1-502 Hospitals 3. Good health Gram-positive 03 medical and health sciences Anti-Infective Agents Biofilms antimicrobial Central Venous Catheters Humans fungi Edetic Acid Research Article Calcium Chelating Agents
DOI: 10.1128/msphere.00525-18 Publication Date: 2018-11-27T11:37:48Z
ABSTRACT
The colonization of catheters by microorganisms often precludes their long-term use, which can be a problem for human patients that have few body sites available for new catheters. The colonizing organisms often form biofilms, and increasingly these organisms are resistant to multiple antibiotics, making them difficult to treat. In this article, we have taken microorganisms that are associated with biofilm formation in catheters from two Canadian hospitals and tested them with tetrasodium EDTA, a new antimicrobial catheter lock solution. Tetrasodium EDTA was effective at eliminating Gram-positive, Gram-negative, and fungal species and represents a promising alternative to antibiotic treatment with less chance of the organisms developing resistance. We expect that our results will be of interest to researchers and clinicians and will lead to improved patient care.
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