Tetrasodium EDTA Is Effective at Eradicating Biofilms Formed by Clinically Relevant Microorganisms from Patients’ Central Venous Catheters

• DOI: 10.1128/msphere.00525-18
• Publication Date: 2018-11-27T11:37:48Z
• Authors: Fangning Liu; Satyender Hansra; Gordon Crockford; Wolfgang Köster; Brenda J. Allan; Joseph M. Blondeau; Chantal Lainesse; Aaron P. White
• Keywords: 0301 basic medicine; Canada; antibiotic resistance; Bacteria; EDTA; Fungi; Microbiology; Gram-negative; QR1-502; Hospitals; 3. Good health; Gram-positive; 03 medical and health sciences; Anti-Infective Agents; Biofilms; antimicrobial; Central Venous Catheters; Humans; fungi; Edetic Acid; Research Article; Calcium Chelating Agents

The colonization of catheters by microorganisms often precludes their long-term use, which can be a problem for human patients that have few body sites available for new catheters. The colonizing organisms often form biofilms, and increasingly these organisms are resistant to multiple antibiotics, making them difficult to treat. In this article, we have taken microorganisms that are associated with biofilm formation in catheters from two Canadian hospitals and tested them with tetrasodium EDTA, a new antimicrobial catheter lock solution. Tetrasodium EDTA was effective at eliminating Gram-positive, Gram-negative, and fungal species and represents a promising alternative to antibiotic treatment with less chance of the organisms developing resistance. We expect that our results will be of interest to researchers and clinicians and will lead to improved patient care.