Tetrasodium EDTA Is Effective at Eradicating Biofilms Formed by Clinically Relevant Microorganisms from Patients’ Central Venous Catheters
0301 basic medicine
Canada
antibiotic resistance
Bacteria
EDTA
Fungi
Microbiology
Gram-negative
QR1-502
Hospitals
3. Good health
Gram-positive
03 medical and health sciences
Anti-Infective Agents
Biofilms
antimicrobial
Central Venous Catheters
Humans
fungi
Edetic Acid
Research Article
Calcium Chelating Agents
DOI:
10.1128/msphere.00525-18
Publication Date:
2018-11-27T11:37:48Z
AUTHORS (8)
ABSTRACT
The colonization of catheters by microorganisms often precludes their long-term use, which can be a problem for human patients that have few body sites available for new catheters. The colonizing organisms often form biofilms, and increasingly these organisms are resistant to multiple antibiotics, making them difficult to treat. In this article, we have taken microorganisms that are associated with biofilm formation in catheters from two Canadian hospitals and tested them with tetrasodium EDTA, a new antimicrobial catheter lock solution. Tetrasodium EDTA was effective at eliminating Gram-positive, Gram-negative, and fungal species and represents a promising alternative to antibiotic treatment with less chance of the organisms developing resistance. We expect that our results will be of interest to researchers and clinicians and will lead to improved patient care.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (69)
CITATIONS (33)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....