Tetrasodium EDTA Is Effective at Eradicating Biofilms Formed by Clinically Relevant Microorganisms from Patients’ Central Venous Catheters

• DOI: 10.1128/msphere.00525-18
• Publication Date: 2018-11-27T11:37:48Z
• Authors: Fangning Liu; Satyender Hansra; Gordon Crockford; Wolfgang Köster; Brenda J. Allan; Joseph M. Blondeau; Chantal Lainesse; Aaron P. White
• Keywords: 0301 basic medicine; Canada; antibiotic resistance; Bacteria; EDTA; Fungi; Microbiology; Gram-negative; QR1-502; Hospitals; 3. Good health; Gram-positive; 03 medical and health sciences; Anti-Infective Agents; Biofilms; antimicrobial; Central Venous Catheters; Humans; fungi; Edetic Acid; Research Article; Calcium Chelating Agents

The colonization of catheters by microorganisms often precludes their long-term use, which can be a problem for human patients that have few body sites available new catheters. colonizing organisms form biofilms, and increasingly these are resistant to multiple antibiotics, making them difficult treat. In this article, we taken associated with biofilm formation in from two Canadian hospitals tested tetrasodium EDTA, antimicrobial catheter lock solution. Tetrasodium EDTA was effective at eliminating Gram-positive, Gram-negative, fungal species represents promising alternative antibiotic treatment less chance the developing resistance. We expect our results will interest researchers clinicians lead improved patient care.