Evolution of Early SARS-CoV-2 and Cross-Coronavirus Immunity
0301 basic medicine
cross-reactivity
Pneumonia, Viral
Medizin
Cross Reactions
Antibodies, Viral
Immunity, Heterologous
Microbiology
Betacoronavirus
03 medical and health sciences
COVID-19 Testing
Humans
Molecular Biology
Pandemics
Clinical Laboratory Techniques
SARS-CoV-2
COVID-19
antibody response
QR1-502
Immunity, Humoral
3. Good health
Coronavirus Infections
Fc-receptor binding
Biomarkers
Research Article
DOI:
10.1128/msphere.00622-20
Publication Date:
2020-09-01T14:33:07Z
AUTHORS (10)
ABSTRACT
A critical step to ending the spread of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the ability to detect, diagnose, and understand why some individuals develop mild and others develop severe disease. For example, defining the early evolutionary patterns of humoral immunity to SARS-CoV-2, and whether prevalent coronaviruses or other common infections influence the evolution of immunity, remains poorly understood but could inform diagnostic and vaccine development. Here, we deeply profiled the evolution of SARS-CoV-2 immunity, and how it is influenced by other coinfections. Our data suggest an early and rapid rise in functional humoral immunity in the first 2 weeks of infection across antigen-specific targets, which is negligibly influenced by cross-reactivity to additional common coronaviruses or common respiratory infections. These data suggest that preexisting receptor binding domain-specific immunity does not influence or bias the evolution of immunity to SARS-CoV-2 and should have negligible influence on shaping diagnostic or vaccine-induced immunity.
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