The Influence ofFUT2andFUT3Polymorphisms and Nasopharyngeal Microbiome on Respiratory Infections in Breastfed Bangladeshi Infants from the Microbiota and Health Study

• DOI: 10.1128/msphere.00686-21
• Publication Date: 2021-11-10T15:11:59Z
• Authors: Aristea Binia; Léa Siegwald; Shamima Sultana; Maya Shevlyakova; Gregory Lefebvre; Francis Foata; Séverine Combremont; Aline Charpagne; Karine Vidal; Norbert Sprenger; Mahbubar Rahman; Albert Palleja; Aron C. Eklund; Henrik Bjørn Nielsen; Harald Brüssow; Shafiqul Alam Sarker; Olga Sakwinska
• Keywords: Male; 2. Zero hunger; Bangladesh; 0303 health sciences; Bacteria; Milk, Human; Galactoside 2-alpha-L-fucosyltransferase; FUT2; secretor status; microbiome; Infant; Mothers; Fucosyltransferases; Microbiology; QR1-502; Gastrointestinal Microbiome; 3. Good health; respiratory infections; 03 medical and health sciences; Breast Feeding; Humans; Female; Respiratory Tract Infections; Research Article

The observed risk reduction of acute respiratory infections (ARIs) among infants of secretor mothers during the predominant breastfeeding period is consistent with the hypothesis that fucosylated oligosaccharides in human milk contribute to protection against respiratory infections. Respiratory pathogens were only weak modulators of risk, and the nasopharyngeal microbiome did not influence ARI risk, suggesting that the associated protective effects of human milk oligosaccharides (HMOs) are not conveyed via changes in the nasopharyngeal microbiome.