Alterations in the gut microbiota and its metabolites contribute to metabolic maladaptation in dairy cows during the development of hyperketonemia

• DOI: 10.1128/msystems.00023-24
• Publication Date: 2024-03-19T13:01:28Z
• Authors: Zhengzhong Luo; Zhenlong Du; Yixin Huang; Tao Zhou; Dan Wu; Xueping Yao; Liuhong Shen; Shumin Yu; Kang Yong; Baoning Wang; Suizhong Cao
• Keywords: Maladaptation

Metabolic maladaptation in dairy cows after calving can lead to long-term elevation of ketones, such as β-hydroxybutyrate (BHB), representing the condition known hyperketonemia, which greatly influences health and production performance during lactation period. Although gut microbiota is alter with association microbial metabolites development hyperketonemia remains unknown. In this study, we performed a multi-omics analysis investigate associations between fecal community, fecal/plasma metabolites, serum markers hyperketonemic transition Dynamic changes abundance phyla Verrucomicrobiota Proteobacteria were detected cows, an adaptation enhanced lipolysis abnormal glucose metabolism calving. Random forest univariate analyses indicated that