Gut Microbiome Alterations Associated with Diabetes in Mexican Americans in South Texas

• DOI: 10.1128/msystems.00033-22
• Publication Date: 2022-04-28T08:30:32Z
• Authors: Suet-Ying Kwan; Caroline M. Sabotta; Aron Joon; Peng Wei; Lauren E. Petty; Jennifer E. Below; Xiaogang Wu; Jianhua Zhang; Robert R. Jenq; Ernest T. Hawk; Joseph B. McCormick; Susan P. Fisher-Hoch; Laura Beretta
• Keywords: 0301 basic medicine; diabetes; gut microbiome; Mexican American population; Microbiology; Texas; metagenome; QR1-502; Gastrointestinal Microbiome; 3. Good health; Butyrates; 03 medical and health sciences; Diabetes Mellitus, Type 2; Enterobacteriaceae; Mexican Americans; Humans; Prospective Studies; health disparity; Research Article

The gut microbiome composition varies across ethnicities and geographical locations, yet studies on diabetes-associated microbiome changes specific to high-risk Mexican Americans are lacking. Here, we aimed to identify specific alterations associated with diabetes in this population, as well as host genetic factors that may explain increased disease susceptibility in this ethnic group.