Case-Control Microbiome Study of Chronic Otitis Media with Effusion in Children Points at Streptococcus salivarius as a Pathobiont-Inhibiting Species

• DOI: 10.1128/msystems.00056-21
• Publication Date: 2021-04-19T14:36:39Z
• Authors: Jennifer Jörissen; Marianne F. L. va...; Ilke De Boeck; Wannes Van Beeck; Stijn Wittouck; An Boudewyns; Paul Van de Heyning; Vedat Topsakal; Vincent Van Rompaey; Ine Wouters; Liesbet Van Heirs...; Pierre Van Damme; Surbi Malhotra-Kumar; Heidi Theeten; Olivier M. Vander...; Sarah Lebeer
• Keywords: 0301 basic medicine; PHARYNGO-TONSILLITIS; INTERFERING ALPHA-STREPTOCOCCI; microbiome; MOLECULAR ANALYSIS; Streptococcus salivarius; Microbiology; ear canal; 03 medical and health sciences; otitis media with effusion; 16S rRNA; UPPER RESPIRATORY-TRACT; Biology; Science & Technology; MIDDLE-EAR; K12; otitis media; upper respiratory tract; GROUP-A STREPTOCOCCUS; GENE; QR1-502; 3. Good health; pediatric; probiotics; middle ear; Life Sciences & Biomedicine; NASAL SPRAY; RESISTANCE; Research Article

The majority of probiotics marketed today target gastrointestinal health. This study searched for bacteria native to the human upper respiratory tract, with a beneficial potential for respiratory and middle ear health.