Multi-omics analysis reveals the associations between altered gut microbiota, metabolites, and cytokines during pregnancy

• DOI: 10.1128/msystems.01252-23
• Publication Date: 2024-02-07T14:01:05Z
• Authors: Ting Huang; Xinyuan Liang; Han Bao; Guangyu Ma; Xiaomei Tang; Huijuan Luo; Xiaomin Xiao
• Keywords: Omics

ABSTRACT For embryo implantation and fetal development, the maternal immune system undergoes dramatic changes. The mechanisms involved in inducing alterations of immunity have not been fully clarified. Gut microbiome metabolites were thought to influence host response. During normal pregnancy, notable changes occur gut microbiota metabolites. However, relationship these function during pregnancy remains unclear. In this study, we examined microbiota, fecal metabolites, plasma cytokines pregnant women non-pregnant women. Our findings revealed that, comparison women, exhibit a significant increase relative abundance Actinobacteriota differences metabolic pathways related bile acid secretion. Furthermore, there was marked reduction pro-inflammatory levels Correlation analyses indicated that may be linked specific bacteria Bacteria within same microbial modules exhibited consistent effects on cytokines, suggesting as functional groups. Mediation analysis further identified certain might through such acids arachidonic acid. propose potential biological connections between bacteria, immunity, which require validation future studies. IMPORTANCE A great number studies focused diseases induced by intestinal microecological disorders imbalances. understanding how interacts with is fundamental studying pathological pregnancies disturbances, has well elucidated. study employed multi-omics discover can impact function. addition, several mediate effect microbes cytokines. offered new insights into our microbiome, metabolome, pregnancy.