Genomic Diversity of Hospital-Acquired Infections Revealed through Prospective Whole-Genome Sequencing-Based Surveillance

• DOI: 10.1128/msystems.01384-21
• Publication Date: 2022-06-13T13:04:25Z
• Authors: Mustapha M. Mustapha; Vatsala R. Srinivasa; Marissa P. Griffith; Shu-Ting Cho; Daniel R. Evans; Kady Waggle; Chinelo Ezeonwuka; Daniel J. Snyder; Jane W. Marsh; Lee H. Harrison; Vaughn S. Cooper; Daria Van Tyne
• Keywords: 0301 basic medicine; 0303 health sciences; hospital-acquired infections; pangenome; Whole Genome Sequencing; Genomics; bacterial evolution; Microbiology; QR1-502; Hospitals; Anti-Bacterial Agents; 3. Good health; 03 medical and health sciences; whole-genome sequencing; horizontal gene transfer; Humans; antimicrobial resistance; Genome, Bacterial; Research Article

Hospitalized patients are at increased risk of becoming infected with antibiotic-resistant organisms. We used whole-genome sequencing to survey and compare over 3,000 clinical bacterial isolates collected from hospitalized patients at a large medical center over a 2-year period.