Fecal Microbial Community Composition in Myeloproliferative Neoplasm Patients Is Associated with an Inflammatory State

• DOI: 10.1128/spectrum.00032-22
• Publication Date: 2022-04-27T13:03:24Z
• Authors: Andrew Oliver; Kenza El Alaoui; Carolyn Haunschild; Julio Avelar-Barr...; Laura F. Mendez L...; Katrine Whiteson; Angela G. Fleischman
• Keywords: 0301 basic medicine; myeloproliferative neoplasm; 610; microbiome; Observation; Microbiology; Feces; 03 medical and health sciences; Rare Diseases; Clinical Research; Neoplasms; 2.1 Biological and endogenous factors; Humans; Cancer; Inflammation; Myeloproliferative Disorders; Hematology; Biological Sciences; cytokines; QR1-502; Gastrointestinal Microbiome; 3. Good health; inflammation; Chronic Disease; Microbiome

MPNs are chronic blood cancers in which inflammation plays a key role in disease initiation, progression, and symptomatology. The gut microbiome modulates normal blood development and inflammation and may also impact the development and manifestation of blood cancers.