Staphylococcus aureus Genomes Harbor Only MpsAB-Like Bicarbonate Transporter but Not Carbonic Anhydrase as Dissolved Inorganic Carbon Supply System

• DOI: 10.1128/spectrum.00970-21
• Publication Date: 2021-11-03T14:30:37Z
• Authors: Sook-Ha Fan; Elisa Liberini; Friedrich Götz
• Keywords: 0301 basic medicine; Staphylococcus aureus; carbonic anhydrase; Anion Transport Proteins; bicarbonate transporter; Firmicutes; Microbial Sensitivity Tests; Microbiology; QR1-502; 3. Good health; Bicarbonates; 03 medical and health sciences; MpsAB; Amino Acid Sequence; Ethoxzolamide; Staphylococcus carnosus; Carbonic Anhydrase Inhibitors; Gene Deletion; Genome, Bacterial; Research Article; Carbonic Anhydrases

The discrepancies in the current literature and even in NCBI database, which listed some protein sequences annotated as Staphylococcus aureus carbonic anhydrase (CA), are misleading. One of the existing problems in publicly available sequence databases is the presence of incorrectly annotated genes, especially if they originated from unfinished genomes.