Effects of Bedaquiline Combined with Fluoroquinolone and/or Clofazimine on QT Interval in Patients with Multidrug-Resistant Tuberculosis: a Retrospective Study

• DOI: 10.1128/spectrum.01048-23
• Publication Date: 2023-06-13T14:01:37Z
• Authors: Rong Li; Jin-Bao Ma; Hong Yang; Han Yang; Xin-Jun Yang; Yan-Qin Wu; Fei Ren
• Keywords: Bedaquiline; Culture conversion; Clofazimine

With the application of bedaquiline (Bdq), success rate multidrug-resistant tuberculosis (MDR-TB) treatment has been significantly improved; however, cardiac safety patients during cannot be ignored. Hence, this study compared effects alone and combined with fluoroquinolones (FQs) and/or clofazimine (CFZ) on QT interval. This single-center retrospective cohort analyzed clinical data MDR-TB treated for 24 weeks from January 2020 to May 2021 in Xi'an Chest Hospital changes QTcF between two groups. Eighty-five were included grouped by types anti-TB drugs affecting interval they used. Group A (