Protein Kinase C Inhibitors Reduce SARS-CoV-2 Replication in Cultured Cells

• DOI: 10.1128/spectrum.01056-22
• Publication Date: 2022-08-24T13:02:14Z
• Authors: Changbai Huang; Fei Feng; Yongxia Shi; Wenhui Li; Ziqiao Wang; Yunkai Zhu; Shuai Yuan; Dandan Hu; Jun Dai; Qiqi Jiang; Rong Zhang; Chao Liu; Ping Zhang
• Keywords: 0301 basic medicine; SARS-CoV-2; translation; Microbiology; Antiviral Agents; QR1-502; COVID-19 Drug Treatment; 3. Good health; 03 medical and health sciences; Humans; Angiotensin-Converting Enzyme 2; PKC; Cells, Cultured; Protein Kinase C; replicon; Research Article

There is an urgent need for effective therapeutic drugs to control the pandemic caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). We found that several inhibitors of protein kinases C (PKCs) dramatically decrease the replication of SARS-CoV-2 in cultured cells.